Non-Genetic Variation Influencing Factors of Dose-Adjusted Blood Concentration of Valproic Acid inChildren with Epilepsy

Li Jing; Nie Songliu; Wang Facai; Jiang Junjie; Yang Shunyin; Gao Yuan; Wang Liyuan; Duan Zihao; Shen Bingxiang

doi:10. 13407/ j. cnki. jpp. 1672-108X. 2023. 10. 001

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Non-Genetic Variation Influencing Factors of Dose-Adjusted Blood Concentration of Valproic Acid inChildren with Epilepsy

更新时间：2023-09-30

- Non-Genetic Variation Influencing Factors of Dose-Adjusted Blood Concentration of Valproic Acid inChildren with Epilepsy
- Vol. 29, Issue 10, Pages: 1-3(2023)
- 作者机构：
  
  安徽医科大学附属六安医院,六安市人民医院,安徽,六安,237005
- 作者简介：
- 基金信息：
- DOI：10. 13407/ j. cnki. jpp. 1672-108X. 2023. 10. 001
  CLC：
- Published：2023，
  
  Published Online：10 October 2023，
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Li Jing, Nie Songliu, Wang Facai, et al. Non-Genetic Variation Influencing Factors of Dose-Adjusted Blood Concentration of Valproic Acid inChildren with Epilepsy. [J]. 29(10):1-3(2023)
DOI：

Li Jing, Nie Songliu, Wang Facai, et al. Non-Genetic Variation Influencing Factors of Dose-Adjusted Blood Concentration of Valproic Acid inChildren with Epilepsy. [J]. 29(10):1-3(2023) DOI： 10. 13407/ j. cnki. jpp. 1672-108X. 2023. 10. 001.

摘要

目的:探讨影响癫痫患儿丙戊酸剂量校正血药浓度[C/ D

单位(μg / mL) / (g / d)]的影响因素

为癫痫患儿个体化用药提供参考。方法:回顾性收集我院 2021 年 166 例癫痫患儿丙戊酸血药浓度监测数据及临床资料

考察性别、年龄、体质量、药物剂型及联合用药对丙戊酸 C/ D 的影响。结果:癫痫患儿丙戊酸的血药浓度为(66. 53± 21. 02) μg / mL

剂量为(0. 53± 0. 23) g / d

C/ D 为(148. 77±82. 91)(μg / mL) / (g / d)。年龄≤3、>3 ~ 6、>6 ~ 16 岁患儿的丙戊酸 C/ D 分别为(256. 59±122. 62)、(157. 17±45. 86)、(112. 46±49. 68)(μg / mL) / (g / d)(P<0. 05);体质量≤20、>20~40、>40 kg 患儿的丙戊酸 C/ D 分别为(204. 80±97. 24)、(124. 05±42. 84)、(90. 88±36. 00)(μg / mL) / (g / d)(P<0. 05);性别及联合用药对患儿丙戊酸 C/ D 无显著影响。结论:对于年龄≤3 岁以及体质量≤20 kg 的癫痫患儿

临床医师应注意适当减少丙戊酸给药剂量

以预防因血药浓度过高而导致不良反应的发生。

Abstract

Objective: To explore the factors that influence the dose-adjusted blood concentration of valproic acid (C/ D

(μg / mL) / (g / d)) in children with epilepsy

so as to provide reference for individualized medication in children with epilepsy. Methods: The monitoring data of blood concentration of valproic acid and clinical data of 166 children with epilepsy admitted into our hospital in 2021 were retrospectively collected

and the effects of gender

age

body wight

drug formulation and drug combination on C/ D of valproic acid were investigated. Results: The blood concentration of valproic acid in children with epilepsy was (66. 53±21. 02) μg / mL

the dose was (0. 53±0. 23) g / d

and the C/ D was (148. 77±82. 91)(μg / mL) / (g / d). The C/ D of valproic acid in children ⩽3 years

from >3 to 6 years

>6 to 16 years were respectively (256. 59±122. 62)

(157. 17±45. 86) and (112. 46±49. 68) (μg / mL) / (g / d) (P<0. 05). The C/ D of valproic acid in children with body weight ⩽20 kg

> 20 to 40 kg

> 40 kg were respectively ( 204. 80± 97. 24)

(124. 05±42. 84) and (90. 88±36. 00)(μg / mL) / (g / d) (P<0. 05). While gender and drug combination had no significant effect on C/ D of valproic acid. Conclusion: For children with epilepsy ⩽3 years and with body weight ⩽20 kg

clinicians should be particularly aware of the need to appropriately reduce the dose of valproic acid

so as to prevent the occurrence of adverse drug reactions due to high blood concentration.

关键词

丙戊酸剂量校正血药浓度癫痫治疗药物监测影响因素

Keywords

valproic aciddose-adjusted blood concentrationepilepsytherapeutic drug monitoringinfluencing factors

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